Osteoarthritis is associated with an increased risk of Parkinson's disease: a population-based longitudinal follow-up study

 Available at: https://doi.org/10.1002/acr.24708

Conclusion.

Findings from this study suggest that osteoarthritis (OA) is associated with an increased risk of developing Parkinson's disease (PD).

In this study.

investigated whether patients with OA are at increased risk of developing PD. Designed as a backward-looking cohort, the study was conducted using the Taiwan Longitudinal Health Insurance Database 2005. 33,360 patients aged 50-64 years with OA between 2002 and 2005 were enrolled, and the comparison The comparison group consisted of 33,360 age- and sex-matched, randomly selected patients with no history of OA.

The results showed that from these groups, the OA group had a significantly higher risk of developing PD, and the PD-free survival rate of the OA group was also significantly lower than that of the comparison group. (p=0.0004)

Subgroup analysis showed that patients with knee or hip OA appeared to have a higher scale of PD risk (aHR 1.55, 95% CI, 1.14-2.11) than patients with OA other than knee and hip (aHR 1.42, 95% CI).