Vitamin K and D deficiencies are independently associated with disease severity in COVID-19 

Open Forum on Infectious Diseases, Volume 8, Issue 10, October 2021, ofab408, https: //doi.org/10.1093/ofid/ofab408

Commentary

This study investigated the association between vitamin K and vitamin D and COVID-19 results.

Results included 150 subjects, 100 COVID-19 + and 50 controls, with a median (interquartile range) age of 55 (48-63) years, 50% of whom were female.

Thirty-four percent reported mild COVID-19 infection, 51% moderate disease, and 15% severe disease, with Dp-ucMGP levels higher (i.e., poorer K status) in COVID-19 + vs. controls (776.5 ng / mL vs. 549.8 ng / mL; P < .0001) and between groups The 25(OH)D was similar between groups. (25.8 vs 21.9 ng) / mL; P= .09).

Participants with vitamin D deficiency (<20 ng / mL) had worse vitamin K status (dp-ucMGP> 780 ng / mL), resulting in experiencing the most severe COVID-19 consequences.

In the adjusted model, every 1-unit increase in log2 dp-ucMGP nearly doubled the odds of acute severe disease and death (AOR, 1.84; 95% CI, 1.01-3.45), and every 1-unit decrease in the natural logarithm of 25 (OH)D was associated with more than 3 times the likelihood of severe COVID-19 disease and (AOR, 0.29). (AOR, 0.29; 95% CI, 0.11-0.67)