Do exercise-related genes explain phenotypic differences in the three components of fitness? A systematic review and meta-analysis
Publication date: October 14, 2021
https://doi.org/10.1371/journal.pone.0249501
DESCRIPTION
In this systematic review and meta-analysis, three components of fitness, namely
Cardiovascular fitness
Muscle strength
Anaerobic fitness
It investigated the identification of candidate genes associated with these and how these relate to phenotypic variability in exercise response.
A total of 3,969 relevant articles were identified from participants who had not previously been trained. After assessment of eligibility and study selection, 24 studies with a total of 3,012 participants were selected for meta-analysis (male n = 1,512; female n = 1,239; not stated n = 261; age 28 ± 9 years).
Analysis of the training group data showed significantly different phenotypic responses. Subgroup analysis found that 44%, 72%, and 10% of the variance in responses in the aerobic, strength, and power phenotypes was explained by genetic effects, and genetic diversity explained a significant proportion of the differences in adaptation across the three components of fitness in participants after training.
