Markers of water intake and hydration are associated with cardiovascular metabolic risk biomarkers in community-dwelling older adults: a cross-sectional analysis. 

Journal of Nutrition, Volume 151, Issue 10, October 2021, Pages 3205-3213, https: //doi.org/10.1093/jn/nxab233

Commentary

The purpose of this study was to investigate whether higher fluid intake and better hydration are associated with better cardiometabolic health.

In a cross-sectional analysis using general linear models, 2238 participants from the second and first generation Omnicohort of the Framingham Heart Study had an estimated glomerular filtration rate > 30 mL-min -1 and 1.73 m -2 and a validated FFQ for water assessment were.

Of the participants, 2219 had fasting urine creatinine data and 950 had 24-hour urine creatinine data to assess hydration.

Cardiovascular metabolic risk factors include fasting blood glucose, triglycerides (TG), total cholesterol (TC), HDL cholesterol, and calculated LDL cholesterol. Glycated hemoglobin (HbA1c); C-reactive protein (CRP); and systolic (SBP) and diastolic (DBP) blood pressure were used.

The resulting cohort was 70 years old on average, and 55% were female.

The mean (95% CI) total daily fluid intake was 2098 (2048, 2150) mL for men and 2109 (2063, 2156) mL for women.

Total daily intake of water, beverages (including plain water), and plain water showed a significant positive trend in HDL cholesterol (P <0.01).

TG concentrations were significantly lower among the highest plain water consumers (P <0.05), and 24-hour urinary concentrations measured by creatinine were positively correlated with LDL cholesterol and TG concentrations (P <0.01) and inversely correlated with HDL cholesterol concentrations (P <0.002).

And neither fluid intake nor urinary concentration was associated with glucose or HbA1c (P > 0.05).