KeiS a medical professional

This is a blog about the scientific basis of medicine. A judo therapist reads research papers for study and writes about them.

sponsorlink

HOME/Post-traumatic stress disorder/

Study Finds Post-Traumatic Stress Disorder Reduced by Trihexyphenidyl, a Centrally-Acting Anticholinergic Drug.

Tuesday, July 6, 2021

Post-traumatic stress disorder

Study Finds Post-Traumatic Stress Disorder Reduced by Trihexyphenidyl, a Centrally-Acting Anticholinergic Drug

The centrally acting anticholinergic drug trihexyphenidyl is very effective in reducing nightmares associated with post-traumatic stress disorder

First published: May 14, 2021 https://doi.org/10.1002/brb3.2147

Commentary

Following a case study of the anticholinergic drug scopolamine butyl bromide, this study investigates the effects of a central anticholinergic drug on post-traumatic stress disorder (PTSD)-related flashbacks and nightmares.

We administered trihexyphenidyl (TP) fireproofing to 34 patients with PTSD-related nightmares and flashbacks who had previously received psychiatric treatment for about 2-15 had been on for years without treatment effect.

The effects of TP were determined using the Clinician-Administered PTSD Scale (CAPS) and the Impact of Events Scale - Revised (IES-R).

As a result, most patients reported no or mild improvement in the CAPS for nightmares (88%) and flashbacks (79%).

Conclusion

This study is the first to demonstrate the potential efficacy of TP in the treatment of refractory PTSD-related nightmares and flashbacks; further double-blind randomized controlled trials are needed to investigate the potential clinical benefits of TP in PTSD.

QooQ