Dynamics of SARS-CoV-2 antibodies and transmission from community-wide serological testing in an Italian Vo 'municipality

Drigatti, I., Ravezzo, E., Manuto, L., et al. SARS-CoV-2 antibody dynamics and infection from community-wide serological testing in Italian Vo ' municipalities. nat commun 12, 4383 (2021). https://doi.org/10.1038/s41467-021-24622-7

Commentary

This is a study in which, in February and March 2020, two mass swab testing campaigns were carried out in Vo ' Italy, and in May 2020, 86% of the Vo ' population was tested using three immunoassays detecting spikes, antibodies to nucleocapsid antigens, neutralization assays, and polymerase chain reaction (PCR).

Subjects who were found to have positive PCR in February/March or serological assays in May were tested again in November and report on the results of the analysis of the May and November surveys.

The seroprevalence in May was estimated to be 3.5% (95% confidence interval (CrI): 2.8-4.3%), and in November, 98.8% (95% confidence interval (CI): 93.7-100.0%) of the sera that tested positive in May reacted to at least one antigen. sera tested positive for at least one antigen.

18.6% (95% CI: 11.0-28.5%) showed an increase in antibodies, or neutralizing reactivity, since May, and analysis of the serostatus of members of 1 118 households showed a susceptible-infectious transmission probability of 26.0% (95% CrI: 17.2-36.9%). Indicates.

The results show that contact tracing has only a limited impact on epidemic control.