High coffee consumption, high brain volume, risk of dementia and stroke

https://doi.org/10.1080/1028415X.2021.1945858

Explanation

This study will investigate whether habitual coffee consumption is associated with differences in brain mass and odds of dementia and stroke.

We conducted a prospective analysis of habitual coffee consumption in 398,646 UK Biobank participants (aged 37-73 years) from 17,702 participants with MRI information. Covariate-adjusted linear regression was used to analyze the association with brain volume, and logistic regression was used to analyze the association with odds of dementia and stroke.

The results showed an inverse linear association between habitual coffee consumption and whole brain (fully adjusted β per cup -1.42, 95% CI -1.89, -0.94), gray matter (β -0.91, 95% CI -1.20, -0.62), and white matter. (β-0.51, 95% CI -0.83, -0.19)

The association between hippocampal volume (β-0.01, 95% CI -0.02, -0.003), white matter high signal (WMH) volume (β- 0.01, 95% CI -0.07, 0.05), coffee consumption and dementia was non-linear. (P nonlinearity = 0.0001)

Compared to light coffee drinkers, there was evidence of higher odds for non-coffee drinkers and decaf coffee drinkers, as well as for those drinking more than 6 cups per day.

After full covariate adjustment, consumption of more than 6 cups/day was found to be associated with 53% higher odds of dementia and stroke compared to consumption of 1-2 cups/day.

The results of this analysis indicate that higher coffee consumption reduces total brain mass and increases the odds of dementia.