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A study investigating the need for COVID-19 vaccination of previously infected individuals.

Tuesday, June 8, 2021

COVID-19

Need for COVID-19 vaccination of previously infected individuals

The Need for COVID-19 Vaccination of Previously Infected Individuals

Nabin K. Shrestha, Patrick C. Burke, Amy S. Nowacki, Paul Terpeluk, Stephen M. Gordon

medRxiv 2021.06.01.21258176; Doi: https : //doi.org/10.1101/2021.06.01.21258176

Explanation

Please note that this study is a preprint and should be interpreted with caution.

The purpose of the study is to investigate whether individuals with a history of SARS-CoV-2 infection have a need for COVID-19 vaccination.

Subjects who tested positive for SARS-CoV-2 approximately 42 days prior were considered to have a history of infection, a condition in which they were considered to have received the vaccination 4 days after receiving the second dose. As a result, of the 52238 employees, 1359 (53%) of 2579 previously infected subjects were not vaccinated, while 22777 (41%) of 49659 previously uninfected subjects were not vaccinated. The cumulative incidence of SARS-CoV-2 infection remained nearly zero among unvaccinated participants with no history of infection, vaccinated participants with a history of infection, and vaccinated previously infected participants. Of the 1359 previously infected participants who remained unvaccinated, none were infected with SARS-CoV-2 during the study period.

In conclusion,

individuals with a history of SARS-CoV-2 infection are unlikely to benefit from vaccination, and it is suggested that vaccine be offered preferentially to those without a history of infection.

In summary, 

the cumulative incidence of COVID-19 was studied in 52238 employees of a US health care system, and of 2579 previously infected with COVID-19, including 1359 who were not vaccinated, the study found that COVID-19 did not occur in anyone during the 5-month study period.

A limitation is that these numbers may be variable, as people may have a history of infection but be asymptomatic and therefore not be considered infected. And since the follow-up period was only 5 months, the long-term effects are unknown.

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