COVID-19 and mRNA Vaccines
The mRNACOVID-19 vaccine has been shown to be effective in preventing symptomatic SARS-CoV-2 infection in a randomized, placebo-controlled phase III trial.
3,950 health care workers, including
A prospective cohort of 3,950 health care workers, first responders, and other workers completed weekly SARS-CoV-2 testing for 13 consecutive weeks and found that under real-world conditions, the efficacy of full immunization (at least 14 days after the second dose) mRNA vaccine was 90% against SARS-CoV-2 infection, regardless of symptomatic status.
The vaccine efficacy for partial immunization (more than 14 days after the first dose and before the second dose) was 80%.
Results.
The licensed mRNACOVID-19 vaccine is effective in preventing SARS-CoV-2 infection, and COVID-19 vaccination is considered recommended for all eligible individuals.
Thompson MG, Burgess JL, Naleway AL, et al. Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS- Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS- CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers - Eight U.S. Locations, December 2020-March 2021. MMWR Morb Mortal Wkly Rep 2021;70:495-500. DOI: http://dx.doi.org/10.15585/mmwr.mm7013e3 external icon.
Summary
The results of this study show that the mRNACOVID-19 vaccine is effective, and it is up to you to decide what you think of this percentage. What you think of this percentage is up to you. 80-90% efficacy in terms of gaining immunity was shown, but 10-20% of people may consider the lack of efficacy as "not perfect" or "uncertain".
There are three limitations to this study: first, the efficacy figures are confirmed by PCR testing after immunization, but the number of infections is limited. Secondly, there is the possibility of mishaps in the collection and shipment of specimens. Finally, there is no confirmation in the period after immunization from the vaccine.
Because of these limitations, the actual results may vary, so the experimental results are not absolute and may not be reproducible in some cases.
And behind the scenes, many of the researchers and medical professionals who are involved in these activities seem to overly dramatize the small number of cases that have occurred and say that vaccines are ineffective or a conspiracy. The effectiveness of the vaccine itself has been confirmed, and side effects and ineffectiveness are just as common as with any other vaccine.
However, the vaccine also has the purpose of gaining herd immunity, and by vaccinating a large number of people, it can limit the spread of the disease, which is also a measure against COVID-19. Future research may change these results, but the evidence currently available suggests that this is one of the most believable results.
