Safety of vaccines used for routine immunization in the United States: an updated systematic review and meta-analysis
Through numerous studies, few associations between vaccines and serious major adverse events have been found. However, it is difficult to investigate rare events. Adverse events need to be compared with the preventive effect provided by the vaccine.
https://doi.org/10.1016/j.vaccine.2021.03.079
Commentary
The purpose of this study was to conduct a systematic review of the safety of vaccines recommended for children, adults, and pregnant women in the United States and to demonstrate their safety. The study updated a 2014 U.S. Agency for Healthcare Research and Quality review by searching the literature and integrating newly available data in November 2020.
Studies of vaccines that used a comparator and reported the presence or absence of major adverse events were eligible, and the strength of evidence (SoE) of all evidence statements was assessed according to the Center for Evidence-Based Practice methodology.
As a result, of the 56,603 reviewed citations, 338 studies reported in 518 publications met the selection criteria and are thus these reviews.
In children, the decision was that the SoE was high because there was no increased risk of autism after measles, mumps, and rubella (MMR) vaccination. It was also high because of the increased risk of febrile convulsions with MMR. No evidence of increased risk, intussusception and rotavirus vaccine The latest follow-up (moderate SoE) had no evidence of increased risk or insufficient evidence of major adverse events with new vaccines such as NOR (high SoE) diabetes, 9-valent human papillomavirus
For adults, influenza vaccine and recombinant adjuvanted shingles vaccine have no evidence of increased risk (altered SOE) or insufficient evidence for significant adverse events for novel adjuvanted, inactivated No evidence of increased risk of major adverse events in pregnant women (changes in SoE) after acellular pertussis vaccination, including tetanus, diphtheria, and stillbirth (moderate SoE) was found.
