Lockdown and infection risk
The purpose of this study will be to estimate the incidence of illnesses that may have been caused by SARS-CoV-2 infection during the lockdown period and to identify associated risk factors.
France.
Participants from three adult cohorts of the general population were invited to participate in a study on COVID-19. The main outcome was COVID-19-like symptoms (CLS), defined as a sudden onset of cough, fever, dyspnea, loss of taste and/or anosmia, lasting more than 3 days and occurring in the 17 days prior to the study. A delayed entry Cox model was used to identify relevant factors.
As a result.
Between April 2, 2020 and May 12, 2020, 279,478 participants were invited, 116,903 validated the questionnaire, and 106,848 were included in the analysis; during 62,099 person-months of follow-up, 335 CLS were reported.
The cumulative incidence of CLS was 6.2% on day 15 and 8.8% on day 45 of the blockade, and the risk of CLS was lower when at least one child, or adolescent, lived in the city, which had a population of more than 100,000, and in older age groups in areas of France with a higher prevalence of SARS-CoV-2 infection. The prevalence of SARS-CoV-2 infection was lower in older age groups in regions of France with higher prevalence.
Risk factors included
・People who are overweight or obese
・People with chronic respiratory diseases
・People with anxiety or depression
・Diabetes
・People with chronic diseases other than cancer
are listed.
In conclusion, with regard to the incidence rate in the general population, it remains high for the first two weeks of the lockdown, but tends to decrease gradually.
Carrat, F., Touvier, M., Severi, G. et al. Incidence and risk factors of COVID-19-like symptoms in the French general population during the lockdown period: a multi-cohort study. BMC Infect Dis 21, 169 (2021). Available at: https://doi.org/10.1186/s12879-021-05864-8
Summary
The cumulative incidence at 45 days after the start of lockdown ranged from 7.7 to 10.2%, and the corresponding cases were about 60% of the previous cases in the study.Among the participants, 28% of those with COVID-19-like symptoms sought medical attention, and 40% of those with symptoms followed the lockdown and refrained from going out. In addition, serological studies show that the risk of infection decreases with age, but the risk of severe disease when it does occur increases.
There is also concern that among the source routes of infection, the environment in which the family is formed, including one child or adolescent, plays an important role in the spread of the disease, and obese people are suspected to be more susceptible.
While we know that people with respiratory diseases and chronic illnesses are more susceptible to infection, we also found that people with anxiety and depression are more likely to report COVID-19-like symptoms.This is thought to be due in part to excessive reporting of symptoms due to anxiety and depression, and although there have been cases of psychiatric disorders being reported during the acute phase of infection, the authors explain that we should be cautious in explaining the reverse causality of this relationship.
